Female Sex Hormone May Increase Survival Time Following Massive Blood Loss

After years of research showing promise that a female sex hormone may prolong survival despite massive loss of blood, University of Alabama at Birmingham researchers received funding from the Combat Casualty Care Research Program, US Army Medical Research and Materiel Command, to conduct human trials.

Irshad Chaudry, Ph.D, and colleagues at UAB discovered, after accidentally receiving female rats for study, that “a dose of the estrogen 17β-estradiol (E2) could protect males and females against septicemia…The estrogen affects the immune system and cardiovascular responses, which typically are profoundly depressed after trauma.”

In follow-on studies, Chaudry and his colleagues found that E2 could allow survival for three hours without any fluid resuscitation, and long-term survival if fluid resuscitation was provided after three hours.

Chaudry’s 19-year study of the effect of estrogen began at the Shock and Trauma laboratories, Michigan State University, and at the Center for Surgical Research at Brown University School of Medicine. Chaudry moved to UAB in 2000.

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