Archive for the ‘Grants and Awards’ Category

CNTR’s First DoD Research Proposal to be Funded

Tuesday, August 16th, 2016

With a recently announced $4 million Department of Defense grant, the Coalition for National Trauma Research (CNTR) begins an intensive investigation into the causes and mechanisms of U.S. deaths that occur outside of hospital settings. NTI is a coalition member.

The project, officially called Multi-Institutional Multidisciplinary Injury Mortality Investigation in the Civilian Pre-Hospital Environment (MIMIC), aims to evaluate the causes and pathophysiologic mechanisms of pre-hospital deaths in order to determine survivability by mechanism of injury and the appropriateness of EMS response and the care delivered.

Brian J. Eastridge, MD, Clinical Professor of Surgery at the UT Health Science Center at San Antonio and a Colonel in the U.S. Army, is the principal investigator for the MIMIC project. During his active duty service, Dr. Eastridge was the Trauma Consultant to the U.S. Army Surgeon General and co-developer and Director of the Joint Trauma System. His work analyzing causes of combat death, published in the Journal of Trauma and Acute Care Surgery in 2012, determined that 25 percent of those casualties had injuries that were potentially survivable. The MIMIC grant enables a comparable analysis of civilian death.

In partnership with the National Association of Medical Examiners, MIMIC will engage 60-75 clinician/reviewers to form study panels that will review 3,000 pre-hospital deaths in six diverse states and regions across the country. CNTR will also partner with the Johns Hopkins Bloomberg School of Public Health, whose Data Coordinating Center will be employed for data analysis.

The Coalition for National Trauma Research (CNTR) includes the country’s five leading trauma organizations: American Association for the Surgery of Trauma, National Trauma Institute, Eastern Association for the Surgery of Trauma, ACS Committee on Trauma and the Western Trauma Association. As CNTR, these organizations seek consistent and significant federal funding for trauma research, build trauma research infrastructure and advocate for a centralized research agenda to prioritize work in the discipline. Visit for more information.

NTI Studies Gain $1 Million in Funding from the Joint Warfighter Medical Research Program

Wednesday, October 28th, 2015

Funding from the Joint Warfighter Medical Research Program will support the continuation of two studies initially funded by the National Trauma Institute. Deemed to have significance for pre-hospital treatment of the war wounded, the studies by Jay Doucet, MD, University of California at San Diego, and Henry Cryer, MD, University of California at Los Angeles, were selected on the strength of their preliminary results.

Dr. Doucet’s study, Detection and Management of Non-Compressible Hemorrhage Using Vena Cava Ultrasound, postulates that ultrasonic assessment of the inferior vena cava (IVC) can detect and aid management of non-compressible hemorrhage in major trauma victims. As indicated in small clinical studies, observation of the diameter of IVC in both expiration and inspiration, as well as its collapsibility, can be a sensitive indicator of blood volume loss and hemorrhagic shock. Doucet’s study specifically aims to determine how accurate ultrasound assessment of the IVC is, compared to vital signs, as well as the measure’s ability to detect preclinical shock states.

This technique may predict those patients who will require transfusions, surgery or angiographic embolization. Additionally, the study will provide an opportunity to demonstrate the ability of handheld ultrasound devices to detect and monitor hemorrhagic shock in initial trauma care and in the ICU in both civilian and military trauma environments.

The investigation being led by Dr. Cryer, Transfusion Using Stored Fresh Whole Blood (FWB), will determine the appropriate shelf life of FWB by measuring changes in levels of coagulation factors and global clotting potential of banked units over time. Dr. Cryer’s earlier results demonstrated that filtered blood has a filtration lesion resulting in a coagulopathic product and some decrease in clotting capability over 35 days. Platelet transfusion may correct the filtration lesion seen, but further studies are needed to determine the exact timing and ratio of platelet transfusion required.

The follow-on effort will prospectively determine the effectiveness of trauma resuscitation using FWB compared to component therapy and its effects on markers of coagulation, fibrinolysis, inflammation and global hemostatic potential, as well as hospital outcomes including development of coagulopathy, infection, venous thromboembolism, multiple organ failure, total transfusion requirements, and mortality.

The Joint Warfighter Medical Research Program is a program of the Department of Defense Peer Reviewed Medical Research Program (PRMRP). Funding for this program is directed by Congress to “augment and accelerate high priority Department of Defense and Service medical requirements and to continue prior year initiatives that are close to achieving their objectives and yielding a benefit to military medicine.”

NTI Is Awarded $4.6M Contract for Repository and Military-Relevant Research

Wednesday, October 7th, 2015

Research Repository Fact SheetThe National Trauma Institute today announced the award of a $4.6 million Department of Defense Extramural Medical Research grant to develop a National Trauma Research Repository (NTRR) and fund three promising studies with both military and civilian trauma care implications, whose results will be the first to populate the repository.

“Collaboration between military treatment centers and civilian trauma research centers that focuses on combat casualty research priorities is critical to advancing patient care in both military and civilian contexts,” said NTI’s Executive Director Sharon Smith. “With this contract, the DOD is keeping the country’s wounded soldiers as its highest priority by enabling highly qualified civilian trauma centers to continue and add to the work conducted within its Combat Casualty Care Research Program.”

The grant will fund multi-center studies aimed at some significant knowledge gaps, including an evaluation of Ketamine as an alternative to narcotics in treating severe pain following traumatic injury; development of a surgical airway training system to help combat medics, EMT-paramedics, emergency physicians and surgeons develop surgical competency; and a study of a variety of therapies for mitigating vascular trauma injury that results in non-compressible hemorrhage, the leading cause of death on the modern battlefield.

A follow-on to earlier NTI work, a National Trauma Research Repository will enable the synthesis of these and other study data for maximum use. “Because clinical trauma research has largely been accomplished through disconnected efforts, too often these efforts see delays and duplications, inefficiencies and increased costs,” said Dr. Donald Jenkins, the Mayo Clinic’s Director of Trauma, NTI Board member and Principle Investigator on this project. “Among many other benefits, the NTRR will enable repurposing of data to answer additional research questions and provide for pooled data sets with the statistical power necessary to improve statistical significance.

“The ability to make aggregated research data widely available to clinical investigators is critical to reform trauma research and care,” added Jenkins. “While the practice of medicine should be evidence-based, within the field of trauma there is surprisingly little evidence to support clinical practice. A research data repository will ensure maximum utilization of trauma data for translation into evidence-based practice.”

Learn more about the benefits of research repositories.



NTI Study Refutes Dogma of Ventilator Bundle Use to Prevent Ventilator Associated Pneumonia

Friday, March 1st, 2013

Ventilator associated pneumonia (VAP) is the most common serious infection that occurs in severely injured patients. For those who develop VAP, approximately 20% will not survive. While the mainstay of treatment of VAP remains antibiotic therapy, the emphasis from healthcare organizations has been on VAP prevention, and the Institute for Healthcare Improvement has advocated a “bundle” of care maneuvers to help prevent VAP, including stress ulcer prophylaxis, deep venous thrombosis prophylaxis, head-of-bed elevation, and daily sedation vacation with weaning assessment. Although the use of the ventilator bundle has been widely accepted, there is little evidence of its effectiveness. Furthermore, the Centers for Medicare and Medicaid Services have determined that VAP may be preventable with ventilator bundle use, and has threatened to reduce or eliminate payment to hospitals when a patient develops VAP.

The National Trauma Institute’s first completed research study analyzed the efficacy of the ventilator bundle in prevention of ventilator associated pneumonia in trauma patients who were in the Intensive care Unit (ICU) on a ventilator for at least two days. The research study, highlighted in the February issue of the Journal of Trauma and Acute Care Surgery, and first presented at the AAST Annual Meeting in Kauai, was led by Dr. Martin Croce at the University of Tennessee in Memphis, and enrolled over 600 patients at six Level 1 trauma centers nationally.

This study shows that VAP is more likely to occur in male patients, and those with severe chest injury, regardless of the ventilator bundle. Moreover, the study found that use of the ventilator bundle does not prevent or reduce the occurrence of VAP. Ultimately, critical analysis of dogma is important for patient care, and new, innovative means of ventilator associated pneumonia prevention are needed.

NTI’s Funded Research

Thursday, November 29th, 2012

Since September 2009, NTI has issued two national calls for proposals and has received a total of 177 pre-proposals from 32 states and the District of Columbia. After rigorous peer-review, NTI has awarded $3.9 million to 16 proposals – 7 single-center studies and 9 multi-center studies involving 55 centers. The first research outcomes are being achieved.

To find out more about where we are funding research and to read about the trauma projects that are underway, go to NTI’s Research Page:


NTI Awards $2.5 Million to Nine Important Studies

Tuesday, February 15th, 2011

Today, NTI released news of its awards to nine important trauma-related studies that will take place at institutions across the country. In total, NTI distributed $2.5 million in this round of funding.

Study subjects range from blood transfusion using fresh whole blood to delayed splenic rupture to hospital-acquired staph infection, to vitamin therapy for hemorrhaging patients and more. All were selected for their scientific merit, immediate relevance and potential to influence trauma care in the near term. The principal investigators are Suresh Agarwal, MD, Boston Medical Center; Mark Cipolle, MD, PhD, Christiana Care Health System, DE; Henry Cryer, MD, UCLA; Jay Doucet, MD, UC San Diego Medical Center; Robert Maxwell, MD, UT College of Medicine Chattanooga; Lena Napolitano, MD, UM Ann Arbor; Jean-Francois Pittet, MD, UA Birmingham; Marty Schreiber, MD, Oregon Health & Science University; and Ben Zarzaur, MD, MPH, UT Health Science Center Memphis.

To follow the progress of these and other studies funded by NTI, look for updates on our research page.

NTI Makes the Evening News in Story about Funded Research

Thursday, October 28th, 2010

A San Antonio T.V. station ran a story tonight about Dr. Joel Baseman, professor and chair of the Department of Microbiology and Immunology at the University of Texas Health Science Center, who was recently awarded a $190,000 NTI grant to study how a common pathogen sickens ICU patients on ventilators.

In the KENS 5 story, Baseman says the inflammatory response created by the toxin narrows the airway and compromises lung functioning. Eventually, he believes that new therapies can be developed to increase survival of patients at risk of contracting the infection.

UT Health Science Center San Antonio Announces NTI Grant

Tuesday, October 26th, 2010

A $190,000 grant from the National Trauma Institute is enabling microbiologists and surgeons to work together to study how a common pathogen, Mycoplasma pneumoniae, affects ICU patients. Health Science Center researchers will go into ICUs around the country, where they will explore how frequently M. pneumoniae infection occurs among patients on ventilators and how it impacts their outcomes.

Joel B. Baseman, Ph.D., is the study’s principal investigator and chairman of microbiology and immunology at the UT Health Science Center. The discovery of a toxin produced by M. pneumoniae, made in Dr. Baseman’s lab and first described in a 2006 publication, laid the groundwork for this research project.

The study is just one of seven NTI funded this year. NTI supports translational research projects whose results may affect the practice of medicine in the near term.

Read the UTHSC press release.

Extremity Trauma Research Receives a $38 Million Shot in the Arm

Monday, October 11th, 2010

The Department of Defense just awarded $38.6 million to the Major Extremity Trauma Research Consortium (METRC) at Johns Hopkins Bloomberg School of Public Health. This is great news and a very worthwhile investment. NTI Board member and Johns Hopkins professor Ellen MacKenzie said the funding will allow the new research center to determine which treatments work well in addition to exploring bone infection, chronic pain and overall disability associated with extremity trauma.

Now, if only all the OTHER underfunded areas of trauma could gain the same level of funding and attention, the country could perhaps begin to make a dent in the rates of death and disability related to traumatic injury!

DoD Invests in Sangart’s MP4 Molecule Development for Trauma Applications

Thursday, October 7th, 2010

The Department of Defense awarded a $1.1 million grant to Sangart, Inc. to fund pre-clinical development of the MP4 molecule, a product that can provide “targeted oxygen delivery to the capillaries in severely injured trauma patients,” according to Sangart’s press release.

The award is being issued as part of the Defense Medical Research and Development Program, which provides grants in support of research designed to advance state-of-the-art solutions for world-class medical care for U.S. soldiers.